Plasma proteins predict conversion to dementia from prodromal disease
Identifieur interne : 003627 ( Main/Exploration ); précédent : 003626; suivant : 003628Plasma proteins predict conversion to dementia from prodromal disease
Auteurs : Abdul Hye [Royaume-Uni] ; Joanna Riddoch-Contreras [Royaume-Uni] ; Alison L. Baird [Royaume-Uni] ; Nicholas J. Ashton [Royaume-Uni] ; Chantal Bazenet [Royaume-Uni] ; Rufina Leung [Royaume-Uni] ; Eric Westman [Royaume-Uni, Suède] ; Andrew Simmons [Royaume-Uni] ; Richard Dobson [Royaume-Uni] ; Martina Sattlecker [Royaume-Uni] ; Michelle Lupton [Royaume-Uni, Australie] ; Katie Lunnon [Royaume-Uni] ; Aoife Keohane [Royaume-Uni] ; Malcolm Ward [Royaume-Uni] ; Ian Pike [Royaume-Uni] ; Hans Dieter Zucht [Royaume-Uni] ; Danielle Pepin [États-Unis] ; Wei Zheng [États-Unis] ; Alan Tunnicliffe [États-Unis] ; Jill Richardson [Royaume-Uni] ; Serge Gauthier [Canada] ; Hilkka Soininen [Finlande] ; Iwona Kłoszewska [Pologne] ; Patrizia Mecocci [Italie] ; Magda Tsolaki [Grèce] ; Bruno Vellas [France] ; Simon Lovestone [Royaume-Uni]Source :
- Alzheimer's & Dementia [ 1552-5260 ] ; 2014.
Descripteurs français
- KwdFr :
- Apolipoprotéines E (génétique), Courbe ROC, Dosage immunologique, Dysfonctionnement cognitif (diagnostic), Dysfonctionnement cognitif (sang), Démence (diagnostic), Démence (sang), Femelle, Humains, Imagerie par résonance magnétique, Mâle, Protéines du sang (métabolisme), Questionnaire sur l'état mental de Kahn, Statistiques comme sujet, Sujet âgé, Sujet âgé de 80 ans ou plus, Symptômes prodromiques, Valeur prédictive des tests, Études de cohortes, Évolution de la maladie.
- MESH :
- diagnostic : Dysfonctionnement cognitif, Démence.
- génétique : Apolipoprotéines E.
- métabolisme : Protéines du sang.
- sang : Dysfonctionnement cognitif, Démence.
- Courbe ROC, Dosage immunologique, Femelle, Humains, Imagerie par résonance magnétique, Mâle, Questionnaire sur l'état mental de Kahn, Statistiques comme sujet, Sujet âgé, Sujet âgé de 80 ans ou plus, Symptômes prodromiques, Valeur prédictive des tests, Études de cohortes, Évolution de la maladie.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Apolipoproteins E (genetics), Blood Proteins (metabolism), Cognitive Dysfunction (blood), Cognitive Dysfunction (diagnosis), Cohort Studies, Dementia (blood), Dementia (diagnosis), Disease Progression, Female, Humans, Immunoassay, Magnetic Resonance Imaging, Male, Mental Status Schedule, Predictive Value of Tests, Prodromal Symptoms, ROC Curve, Statistics as Topic.
- MESH :
- chemical , genetics : Apolipoproteins E.
- chemical , metabolism : Blood Proteins.
- blood : Cognitive Dysfunction, Dementia.
- diagnosis : Cognitive Dysfunction, Dementia.
- Aged, Aged, 80 and over, Cohort Studies, Disease Progression, Female, Humans, Immunoassay, Magnetic Resonance Imaging, Male, Mental Status Schedule, Predictive Value of Tests, Prodromal Symptoms, ROC Curve, Statistics as Topic.
Abstract
The study aimed to validate previously discovered plasma biomarkers associated with AD, using a design based on imaging measures as surrogate for disease severity and assess their prognostic value in predicting conversion to dementia.
Three multicenter cohorts of cognitively healthy elderly, mild cognitive impairment (MCI), and AD participants with standardized clinical assessments and structural neuroimaging measures were used. Twenty-six candidate proteins were quantified in 1148 subjects using multiplex (xMAP) assays.
Sixteen proteins correlated with disease severity and cognitive decline. Strongest associations were in the MCI group with a panel of 10 proteins predicting progression to AD (accuracy 87%, sensitivity 85%, and specificity 88%).
We have identified 10 plasma proteins strongly associated with disease severity and disease progression. Such markers may be useful for patient selection for clinical trials and assessment of patients with predisease subjective memory complaints.
Url:
DOI: 10.1016/j.jalz.2014.05.1749
PubMed: 25012867
PubMed Central: 4240530
Affiliations:
- Australie, Canada, Finlande, France, Grèce, Italie, Pologne, Royaume-Uni, Suède, États-Unis
- Angleterre, Grand Londres, Midi-Pyrénées, Missouri (État), Occitanie (région administrative), Oxfordshire, Svealand
- Londres, Oxford, Stockholm, Toulouse
- Université d'Oxford
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last="Zucht">Hans Dieter Zucht</name><affiliation wicri:level="1"><nlm:aff id="aff5">Proteome Sciences plc, Research & Development, Proteome Sciences plc, Cobham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Proteome Sciences plc, Research & Development, Proteome Sciences plc, Cobham</wicri:regionArea><wicri:noRegion>Cobham</wicri:noRegion></affiliation></author><author><name sortKey="Pepin, Danielle" sort="Pepin, Danielle" uniqKey="Pepin D" first="Danielle" last="Pepin">Danielle Pepin</name><affiliation wicri:level="2"><nlm:aff id="aff6">Protein Analysis and Detection, EMD Millipore Corporation, St. Charles, MO, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Protein Analysis and Detection, EMD Millipore Corporation, St. Charles, MO</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation wicri:level="2"><nlm:aff id="aff6">Protein Analysis and Detection, EMD Millipore Corporation, St. Charles, MO, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Protein Analysis and Detection, EMD Millipore Corporation, St. Charles, MO</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Tunnicliffe, Alan" sort="Tunnicliffe, Alan" uniqKey="Tunnicliffe A" first="Alan" last="Tunnicliffe">Alan Tunnicliffe</name><affiliation wicri:level="2"><nlm:aff id="aff6">Protein Analysis and Detection, EMD Millipore Corporation, St. Charles, MO, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Protein Analysis and Detection, EMD Millipore Corporation, St. Charles, MO</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Richardson, Jill" sort="Richardson, Jill" uniqKey="Richardson J" first="Jill" last="Richardson">Jill Richardson</name><affiliation wicri:level="1"><nlm:aff id="aff7">Neurosciences Therapy Area Unit, GlaxoSmithKline Medicines Research Centre, Hertfordshire, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurosciences Therapy Area Unit, GlaxoSmithKline Medicines Research Centre, Hertfordshire</wicri:regionArea><wicri:noRegion>Hertfordshire</wicri:noRegion></affiliation></author><author><name sortKey="Gauthier, Serge" sort="Gauthier, Serge" uniqKey="Gauthier S" first="Serge" last="Gauthier">Serge Gauthier</name><affiliation wicri:level="1"><nlm:aff id="aff8">Departments of Neurology & Neurosurgery, Psychiatry, Medicine, McGill Centre for Studies in Aging, Verdun, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Departments of Neurology & Neurosurgery, Psychiatry, Medicine, McGill Centre for Studies in Aging, Verdun</wicri:regionArea><wicri:noRegion>Verdun</wicri:noRegion></affiliation><affiliation><nlm:aff id="aff9">on behalf of GenADA consortium</nlm:aff></affiliation></author><author><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name><affiliation wicri:level="1"><nlm:aff id="aff10">Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation></author><author><name sortKey="Kloszewska, Iwona" sort="Kloszewska, Iwona" uniqKey="Kloszewska I" first="Iwona" last="Kłoszewska">Iwona Kłoszewska</name><affiliation wicri:level="1"><nlm:aff id="aff11">Department of Old Age Psychiatry and Psychotic disorders, Medical University of Lodz, Lodz, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Old Age Psychiatry and Psychotic disorders, Medical University of Lodz, Lodz</wicri:regionArea><wicri:noRegion>Lodz</wicri:noRegion></affiliation></author><author><name sortKey="Mecocci, Patrizia" sort="Mecocci, Patrizia" uniqKey="Mecocci P" first="Patrizia" last="Mecocci">Patrizia Mecocci</name><affiliation wicri:level="1"><nlm:aff id="aff12">Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Gerontology and Geriatrics, University of Perugia, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name><affiliation wicri:level="1"><nlm:aff id="aff13">3rd Department of Neurology, Aristotle University, Thessaloniki, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>3rd Department of Neurology, Aristotle University, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Vellas, Bruno" sort="Vellas, Bruno" uniqKey="Vellas B" first="Bruno" last="Vellas">Bruno Vellas</name><affiliation wicri:level="3"><nlm:aff id="aff14">Department of Internal Medicine and Geriatric Medicine, INSERM U 558, University of Toulouse, Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Internal Medicine and Geriatric Medicine, INSERM U 558, University of Toulouse, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Lovestone, Simon" sort="Lovestone, Simon" uniqKey="Lovestone S" first="Simon" last="Lovestone">Simon Lovestone</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institute of Psychiatry, Department of Old Age Psychiatry, King's College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychiatry, Department of Old Age Psychiatry, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff15">Department of Psychiatry, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychiatry, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName 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uniqKey="Hye A" first="Abdul" last="Hye">Abdul Hye</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institute of Psychiatry, Department of Old Age Psychiatry, King's College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychiatry, Department of Old Age Psychiatry, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Riddoch Contreras, Joanna" sort="Riddoch Contreras, Joanna" uniqKey="Riddoch Contreras J" first="Joanna" last="Riddoch-Contreras">Joanna Riddoch-Contreras</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institute of Psychiatry, Department of Old Age Psychiatry, King's College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychiatry, Department of Old Age Psychiatry, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Baird, Alison L" sort="Baird, Alison L" uniqKey="Baird A" first="Alison L." last="Baird">Alison L. Baird</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institute of Psychiatry, Department of Old Age Psychiatry, King's College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychiatry, Department of Old Age Psychiatry, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ashton, Nicholas J" sort="Ashton, Nicholas J" uniqKey="Ashton N" first="Nicholas J." last="Ashton">Nicholas J. Ashton</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institute of Psychiatry, Department of Old Age Psychiatry, King's College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychiatry, Department of Old Age Psychiatry, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Bazenet, Chantal" sort="Bazenet, Chantal" uniqKey="Bazenet C" first="Chantal" last="Bazenet">Chantal Bazenet</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institute of Psychiatry, Department of Old Age Psychiatry, King's College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychiatry, Department of Old Age Psychiatry, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Leung, Rufina" sort="Leung, Rufina" uniqKey="Leung R" first="Rufina" last="Leung">Rufina Leung</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institute of Psychiatry, Department of Old Age Psychiatry, King's College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychiatry, Department of Old Age Psychiatry, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Westman, Eric" sort="Westman, Eric" uniqKey="Westman E" first="Eric" last="Westman">Eric Westman</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institute of Psychiatry, Department of Old Age Psychiatry, King's College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychiatry, Department of Old Age Psychiatry, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">Department of Neurobiology Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Neurobiology Care Sciences and Society, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Simmons, Andrew" sort="Simmons, Andrew" uniqKey="Simmons A" first="Andrew" last="Simmons">Andrew Simmons</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institute of Psychiatry, Department of Old Age Psychiatry, King's College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychiatry, Department of Old Age Psychiatry, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Dobson, Richard" sort="Dobson, Richard" uniqKey="Dobson R" first="Richard" last="Dobson">Richard Dobson</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institute of Psychiatry, Department of Old Age Psychiatry, King's College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychiatry, Department of Old Age Psychiatry, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sattlecker, Martina" sort="Sattlecker, Martina" uniqKey="Sattlecker M" first="Martina" last="Sattlecker">Martina Sattlecker</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institute of Psychiatry, Department of Old Age Psychiatry, King's College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychiatry, Department of Old Age Psychiatry, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lupton, Michelle" sort="Lupton, Michelle" uniqKey="Lupton M" first="Michelle" last="Lupton">Michelle Lupton</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institute of Psychiatry, Department of Old Age Psychiatry, King's College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychiatry, Department of Old Age Psychiatry, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Neuroimaging Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Neuroimaging Genetics, QIMR Berghofer Medical Research Institute, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Lunnon, Katie" sort="Lunnon, Katie" uniqKey="Lunnon K" first="Katie" last="Lunnon">Katie Lunnon</name><affiliation wicri:level="1"><nlm:aff id="aff4">University of Exeter Medical School, Exeter University, Exeter, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Exeter Medical School, Exeter University, Exeter</wicri:regionArea><wicri:noRegion>Exeter</wicri:noRegion></affiliation></author><author><name sortKey="Keohane, Aoife" sort="Keohane, Aoife" uniqKey="Keohane A" first="Aoife" last="Keohane">Aoife Keohane</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institute of Psychiatry, Department of Old Age Psychiatry, King's College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychiatry, Department of Old Age Psychiatry, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ward, Malcolm" sort="Ward, Malcolm" uniqKey="Ward M" first="Malcolm" last="Ward">Malcolm Ward</name><affiliation wicri:level="1"><nlm:aff id="aff5">Proteome Sciences plc, Research & Development, Proteome Sciences plc, Cobham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Proteome Sciences plc, Research & Development, Proteome Sciences plc, Cobham</wicri:regionArea><wicri:noRegion>Cobham</wicri:noRegion></affiliation></author><author><name sortKey="Pike, Ian" sort="Pike, Ian" uniqKey="Pike I" first="Ian" last="Pike">Ian Pike</name><affiliation wicri:level="1"><nlm:aff id="aff5">Proteome Sciences plc, Research & Development, Proteome Sciences plc, Cobham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Proteome Sciences plc, Research & Development, Proteome Sciences plc, Cobham</wicri:regionArea><wicri:noRegion>Cobham</wicri:noRegion></affiliation></author><author><name sortKey="Zucht, Hans Dieter" sort="Zucht, Hans Dieter" uniqKey="Zucht H" first="Hans Dieter" last="Zucht">Hans Dieter Zucht</name><affiliation wicri:level="1"><nlm:aff id="aff5">Proteome Sciences plc, Research & Development, Proteome Sciences plc, Cobham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Proteome Sciences plc, Research & Development, Proteome Sciences plc, Cobham</wicri:regionArea><wicri:noRegion>Cobham</wicri:noRegion></affiliation></author><author><name sortKey="Pepin, Danielle" sort="Pepin, Danielle" uniqKey="Pepin D" first="Danielle" last="Pepin">Danielle Pepin</name><affiliation wicri:level="2"><nlm:aff id="aff6">Protein Analysis and Detection, EMD Millipore Corporation, St. Charles, MO, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Protein Analysis and Detection, EMD Millipore Corporation, St. Charles, MO</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation wicri:level="2"><nlm:aff id="aff6">Protein Analysis and Detection, EMD Millipore Corporation, St. Charles, MO, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Protein Analysis and Detection, EMD Millipore Corporation, St. Charles, MO</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Tunnicliffe, Alan" sort="Tunnicliffe, Alan" uniqKey="Tunnicliffe A" first="Alan" last="Tunnicliffe">Alan Tunnicliffe</name><affiliation wicri:level="2"><nlm:aff id="aff6">Protein Analysis and Detection, EMD Millipore Corporation, St. Charles, MO, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Protein Analysis and Detection, EMD Millipore Corporation, St. Charles, MO</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Richardson, Jill" sort="Richardson, Jill" uniqKey="Richardson J" first="Jill" last="Richardson">Jill Richardson</name><affiliation wicri:level="1"><nlm:aff id="aff7">Neurosciences Therapy Area Unit, GlaxoSmithKline Medicines Research Centre, Hertfordshire, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurosciences Therapy Area Unit, GlaxoSmithKline Medicines Research Centre, Hertfordshire</wicri:regionArea><wicri:noRegion>Hertfordshire</wicri:noRegion></affiliation></author><author><name sortKey="Gauthier, Serge" sort="Gauthier, Serge" uniqKey="Gauthier S" first="Serge" last="Gauthier">Serge Gauthier</name><affiliation wicri:level="1"><nlm:aff id="aff8">Departments of Neurology & Neurosurgery, Psychiatry, Medicine, McGill Centre for Studies in Aging, Verdun, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Departments of Neurology & Neurosurgery, Psychiatry, Medicine, McGill Centre for Studies in Aging, Verdun</wicri:regionArea><wicri:noRegion>Verdun</wicri:noRegion></affiliation><affiliation><nlm:aff id="aff9">on behalf of GenADA consortium</nlm:aff></affiliation></author><author><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name><affiliation wicri:level="1"><nlm:aff id="aff10">Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation></author><author><name sortKey="Kloszewska, Iwona" sort="Kloszewska, Iwona" uniqKey="Kloszewska I" first="Iwona" last="Kłoszewska">Iwona Kłoszewska</name><affiliation wicri:level="1"><nlm:aff id="aff11">Department of Old Age Psychiatry and Psychotic disorders, Medical University of Lodz, Lodz, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Old Age Psychiatry and Psychotic disorders, Medical University of Lodz, Lodz</wicri:regionArea><wicri:noRegion>Lodz</wicri:noRegion></affiliation></author><author><name sortKey="Mecocci, Patrizia" sort="Mecocci, Patrizia" uniqKey="Mecocci P" first="Patrizia" last="Mecocci">Patrizia Mecocci</name><affiliation wicri:level="1"><nlm:aff id="aff12">Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Gerontology and Geriatrics, University of Perugia, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name><affiliation wicri:level="1"><nlm:aff id="aff13">3rd Department of Neurology, Aristotle University, Thessaloniki, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>3rd Department of Neurology, Aristotle University, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Vellas, Bruno" sort="Vellas, Bruno" uniqKey="Vellas B" first="Bruno" last="Vellas">Bruno Vellas</name><affiliation wicri:level="3"><nlm:aff id="aff14">Department of Internal Medicine and Geriatric Medicine, INSERM U 558, University of Toulouse, Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Internal Medicine and Geriatric Medicine, INSERM U 558, University of Toulouse, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Lovestone, Simon" sort="Lovestone, Simon" uniqKey="Lovestone S" first="Simon" last="Lovestone">Simon Lovestone</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institute of Psychiatry, Department of Old Age Psychiatry, King's College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychiatry, Department of Old Age Psychiatry, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff15">Department of Psychiatry, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychiatry, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation><nlm:aff id="aff16">on behalf of AddNeuroMed consortium</nlm:aff></affiliation></author></analytic><series><title level="j">Alzheimer's & Dementia</title><idno type="ISSN">1552-5260</idno><idno type="eISSN">1552-5279</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Apolipoproteins E (genetics)</term><term>Blood Proteins (metabolism)</term><term>Cognitive Dysfunction (blood)</term><term>Cognitive Dysfunction (diagnosis)</term><term>Cohort Studies</term><term>Dementia (blood)</term><term>Dementia (diagnosis)</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Immunoassay</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Mental Status Schedule</term><term>Predictive Value of Tests</term><term>Prodromal Symptoms</term><term>ROC Curve</term><term>Statistics as Topic</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Apolipoprotéines E (génétique)</term><term>Courbe ROC</term><term>Dosage immunologique</term><term>Dysfonctionnement cognitif (diagnostic)</term><term>Dysfonctionnement cognitif (sang)</term><term>Démence (diagnostic)</term><term>Démence (sang)</term><term>Femelle</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Mâle</term><term>Protéines du sang (métabolisme)</term><term>Questionnaire sur l'état mental de Kahn</term><term>Statistiques comme sujet</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Symptômes prodromiques</term><term>Valeur prédictive des tests</term><term>Études de cohortes</term><term>Évolution de la maladie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Apolipoproteins E</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Blood Proteins</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Cognitive Dysfunction</term><term>Dementia</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cognitive Dysfunction</term><term>Dementia</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Dysfonctionnement cognitif</term><term>Démence</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Apolipoprotéines E</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines du sang</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Dysfonctionnement cognitif</term><term>Démence</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Cohort Studies</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Immunoassay</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Mental Status Schedule</term><term>Predictive Value of Tests</term><term>Prodromal Symptoms</term><term>ROC Curve</term><term>Statistics as Topic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Courbe ROC</term><term>Dosage immunologique</term><term>Femelle</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Mâle</term><term>Questionnaire sur l'état mental de Kahn</term><term>Statistiques comme sujet</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Symptômes prodromiques</term><term>Valeur prédictive des tests</term><term>Études de cohortes</term><term>Évolution de la maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The study aimed to validate previously discovered plasma biomarkers associated with AD, using a design based on imaging measures as surrogate for disease severity and assess their prognostic value in predicting conversion to dementia.</p></sec><sec><title>Methods</title><p>Three multicenter cohorts of cognitively healthy elderly, mild cognitive impairment (MCI), and AD participants with standardized clinical assessments and structural neuroimaging measures were used. Twenty-six candidate proteins were quantified in 1148 subjects using multiplex (xMAP) assays.</p></sec><sec><title>Results</title><p>Sixteen proteins correlated with disease severity and cognitive decline. Strongest associations were in the MCI group with a panel of 10 proteins predicting progression to AD (accuracy 87%, sensitivity 85%, and specificity 88%).</p></sec><sec><title>Conclusions</title><p>We have identified 10 plasma proteins strongly associated with disease severity and disease progression. Such markers may be useful for patient selection for clinical trials and assessment of patients with predisease subjective memory complaints.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hye, A" uniqKey="Hye A">A. Hye</name></author><author><name sortKey="Lynham, S" uniqKey="Lynham S">S. Lynham</name></author><author><name sortKey="Thambisetty, M" uniqKey="Thambisetty M">M. Thambisetty</name></author><author><name sortKey="Causevic, M" uniqKey="Causevic M">M. Causevic</name></author><author><name sortKey="Campbell, J" uniqKey="Campbell J">J. Campbell</name></author><author><name sortKey="Byers, H L" uniqKey="Byers H">H.L. Byers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cutler, P" uniqKey="Cutler P">P. Cutler</name></author><author><name sortKey="Akuffo, E L" uniqKey="Akuffo E">E.L. Akuffo</name></author><author><name sortKey="Bodnar, W M" uniqKey="Bodnar W">W.M. Bodnar</name></author><author><name sortKey="Briggs, D M" uniqKey="Briggs D">D.M. Briggs</name></author><author><name sortKey="Davis, J B" uniqKey="Davis J">J.B. Davis</name></author><author><name sortKey="Debouck, C M" uniqKey="Debouck C">C.M. Debouck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Akuffo, E L" uniqKey="Akuffo E">E.L. Akuffo</name></author><author><name sortKey="Davis, J B" uniqKey="Davis J">J.B. 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Pirraglia</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>Canada</li><li>Finlande</li><li>France</li><li>Grèce</li><li>Italie</li><li>Pologne</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Midi-Pyrénées</li><li>Missouri (État)</li><li>Occitanie (région administrative)</li><li>Oxfordshire</li><li>Svealand</li></region><settlement><li>Londres</li><li>Oxford</li><li>Stockholm</li><li>Toulouse</li></settlement><orgName><li>Université d'Oxford</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Hye, Abdul" sort="Hye, Abdul" uniqKey="Hye A" first="Abdul" last="Hye">Abdul Hye</name></region><name sortKey="Ashton, Nicholas J" sort="Ashton, Nicholas J" uniqKey="Ashton N" first="Nicholas J." last="Ashton">Nicholas J. Ashton</name><name sortKey="Baird, Alison L" sort="Baird, Alison L" uniqKey="Baird A" first="Alison L." last="Baird">Alison L. Baird</name><name sortKey="Bazenet, Chantal" sort="Bazenet, Chantal" uniqKey="Bazenet C" first="Chantal" last="Bazenet">Chantal Bazenet</name><name sortKey="Dobson, Richard" sort="Dobson, Richard" uniqKey="Dobson R" first="Richard" last="Dobson">Richard Dobson</name><name sortKey="Keohane, Aoife" sort="Keohane, Aoife" uniqKey="Keohane A" first="Aoife" last="Keohane">Aoife Keohane</name><name sortKey="Leung, Rufina" sort="Leung, Rufina" uniqKey="Leung R" first="Rufina" last="Leung">Rufina Leung</name><name sortKey="Lovestone, Simon" sort="Lovestone, Simon" uniqKey="Lovestone S" first="Simon" last="Lovestone">Simon Lovestone</name><name sortKey="Lovestone, Simon" sort="Lovestone, Simon" uniqKey="Lovestone S" first="Simon" last="Lovestone">Simon Lovestone</name><name sortKey="Lunnon, Katie" sort="Lunnon, Katie" uniqKey="Lunnon K" first="Katie" last="Lunnon">Katie Lunnon</name><name sortKey="Lupton, Michelle" sort="Lupton, Michelle" uniqKey="Lupton M" first="Michelle" last="Lupton">Michelle Lupton</name><name sortKey="Pike, Ian" sort="Pike, Ian" uniqKey="Pike I" first="Ian" last="Pike">Ian Pike</name><name sortKey="Richardson, Jill" sort="Richardson, Jill" uniqKey="Richardson J" first="Jill" last="Richardson">Jill Richardson</name><name sortKey="Riddoch Contreras, Joanna" sort="Riddoch Contreras, Joanna" uniqKey="Riddoch Contreras J" first="Joanna" last="Riddoch-Contreras">Joanna Riddoch-Contreras</name><name sortKey="Sattlecker, Martina" sort="Sattlecker, Martina" uniqKey="Sattlecker M" first="Martina" last="Sattlecker">Martina Sattlecker</name><name sortKey="Simmons, Andrew" sort="Simmons, Andrew" uniqKey="Simmons A" first="Andrew" last="Simmons">Andrew Simmons</name><name sortKey="Ward, Malcolm" sort="Ward, Malcolm" uniqKey="Ward M" first="Malcolm" last="Ward">Malcolm Ward</name><name sortKey="Westman, Eric" sort="Westman, Eric" uniqKey="Westman E" first="Eric" last="Westman">Eric Westman</name><name sortKey="Zucht, Hans Dieter" sort="Zucht, Hans Dieter" uniqKey="Zucht H" first="Hans Dieter" last="Zucht">Hans Dieter Zucht</name></country><country name="Suède"><region name="Svealand"><name sortKey="Westman, Eric" sort="Westman, Eric" uniqKey="Westman E" first="Eric" last="Westman">Eric Westman</name></region></country><country name="Australie"><noRegion><name sortKey="Lupton, Michelle" sort="Lupton, Michelle" uniqKey="Lupton M" first="Michelle" last="Lupton">Michelle Lupton</name></noRegion></country><country name="États-Unis"><region name="Missouri (État)"><name sortKey="Pepin, Danielle" sort="Pepin, Danielle" uniqKey="Pepin D" first="Danielle" last="Pepin">Danielle Pepin</name></region><name sortKey="Tunnicliffe, Alan" sort="Tunnicliffe, Alan" uniqKey="Tunnicliffe A" first="Alan" last="Tunnicliffe">Alan Tunnicliffe</name><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name></country><country name="Canada"><noRegion><name sortKey="Gauthier, Serge" sort="Gauthier, Serge" uniqKey="Gauthier S" first="Serge" last="Gauthier">Serge Gauthier</name></noRegion></country><country name="Finlande"><noRegion><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name></noRegion></country><country name="Pologne"><noRegion><name sortKey="Kloszewska, Iwona" sort="Kloszewska, Iwona" uniqKey="Kloszewska I" first="Iwona" last="Kłoszewska">Iwona Kłoszewska</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Mecocci, Patrizia" sort="Mecocci, Patrizia" uniqKey="Mecocci P" first="Patrizia" last="Mecocci">Patrizia Mecocci</name></noRegion></country><country name="Grèce"><noRegion><name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name></noRegion></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Vellas, Bruno" sort="Vellas, Bruno" uniqKey="Vellas B" first="Bruno" last="Vellas">Bruno Vellas</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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